Polar Capital Holdings PLC
· Added
Change
+1.9M
Date
Q1 2026
XE
| Investor | Type | Est. change | Change | Δ Own | Date | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
Polar Capital Holdings PLC
· Added
Change
+1.9M
Date
Q1 2026
|
Polar Capital Holdings PLC | Added· Q1 2026 | – | +1.9M | – | Q1 2026 | |||||
|
FMR LLC
· Added
Change
+1.9M
Δ Own
+21.3%
Date
Q1 2026
|
FMR LLC | Added· Q1 2026 | – | +1.9M | +21.3% | Q1 2026 | |||||
|
Citadel Advisors LLC
· Added
Change
+1.3M
Δ Own
+100.8%
Date
Q1 2026
|
Citadel Advisors LLC | Added· Q1 2026 | – | +1.3M | +100.8% | Q1 2026 | |||||
|
Alyeska Investment Group, L.P.
· New
Change
+1.3M
Date
Q1 2026
|
Alyeska Investment Group, L.P. | New· Q1 2026 | – | +1.3M | – | Q1 2026 | |||||
|
Deerfield Management Company, L.P.
· Added
Change
+1.1M
Date
Q1 2026
|
Deerfield Management Company, L.P. | Added· Q1 2026 | – | +1.1M | – | Q1 2026 | |||||
|
Commodore Capital LP
· Reduced
Change
−975K
Date
Q1 2026
|
Commodore Capital LP | Reduced· Q1 2026 | – | −975K | – | Q1 2026 | |||||
|
Caligan Partners LP
· Added
Change
+843K
Date
Q1 2026
|
Caligan Partners LP | Added· Q1 2026 | – | +843K | – | Q1 2026 | |||||
|
Capital International Investors
· Reduced
Change
−740K
Date
Q1 2026
|
Capital International Investors | Reduced· Q1 2026 | – | −740K | – | Q1 2026 | |||||
|
Orbimed Advisors LLC
· Added
Change
+613K
Date
Q1 2026
|
Orbimed Advisors LLC | Added· Q1 2026 | – | +613K | – | Q1 2026 | |||||
|
BlackRock
· Added
Change
+540K
Date
Q1 2026
|
BlackRock | Added· Q1 2026 | – | +540K | – | Q1 2026 | |||||
|
Siren, L.L.C.
· Added
Change
+506K
Date
Q1 2026
|
Siren, L.L.C. | Added· Q1 2026 | – | +506K | – | Q1 2026 | |||||
|
Octagon Capital Advisors LP
· New
Change
+490K
Date
Q1 2026
|
Octagon Capital Advisors LP | New· Q1 2026 | – | +490K | – | Q1 2026 | |||||
|
Braidwell LP
· Reduced
Change
−487K
Date
Q1 2026
|
Braidwell LP | Reduced· Q1 2026 | – | −487K | – | Q1 2026 | |||||
|
Novo Holdings A
· New
Change
+485K
Date
Q1 2026
|
Novo Holdings A | New· Q1 2026 | – | +485K | – | Q1 2026 | |||||
|
T. Rowe Price Associates
· Added
Change
+467K
Date
Q1 2026
|
T. Rowe Price Associates | Added· Q1 2026 | – | +467K | – | Q1 2026 | |||||
| Insider | Title | Type | Price | Qty | Value | Owned | ΔOwn | Trade date | Filed date | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Patou Gary
· Director
Sell
−$70K
|
Patou Gary | Director | Sell | $53.14 | −1K | −$70K | 25K | – | Jun 5, 2026 | Jun 8, 2026 | |||||||||
|
Cannon Gillian
· Director
Sell
−$63K
|
Cannon Gillian | Director | Sell | $53.14 | −1K | −$63K | 1K | – | Jun 5, 2026 | Jun 8, 2026 | |||||||||
|
Patou Gary
· Director
2 operations
12K
|
Patou Gary | Director | 2 operations | – | 12K | – | 2K | – | Jun 3, 2026 | Jun 3, 2026 | |||||||||
|
Machado Patrick
· Director
2 operations
12K
|
Machado Patrick | Director | 2 operations | – | 12K | – | 2K | – | Jun 3, 2026 | Jun 3, 2026 | |||||||||
|
Gover Justin D.
· Director
2 operations
12K
|
Gover Justin D. | Director | 2 operations | – | 12K | – | 2K | – | Jun 3, 2026 | Jun 3, 2026 | |||||||||
|
Garofalo Elizabeth A.
· Director
2 operations
12K
|
Garofalo Elizabeth A. | Director | 2 operations | – | 12K | – | 2K | – | Jun 3, 2026 | Jun 3, 2026 | |||||||||
|
Gannon Steven
· Director
2 operations
12K
|
Gannon Steven | Director | 2 operations | – | 12K | – | 2K | – | Jun 3, 2026 | Jun 3, 2026 | |||||||||
|
Cannon Gillian
· Director
2 operations
12K
|
Cannon Gillian | Director | 2 operations | – | 12K | – | 2K | – | Jun 3, 2026 | Jun 3, 2026 | |||||||||
|
Svoronos Dawn
· Director
2 operations
12K
|
Svoronos Dawn | Director | 2 operations | – | 12K | – | 2K | – | Jun 3, 2026 | Jun 3, 2026 | |||||||||
|
Patou Gary
· Director
2 operations
0
|
Patou Gary | Director | 2 operations | – | 0 | – | 0 | – | Jun 1, 2026 | Jun 3, 2026 | |||||||||
|
Machado Patrick
· Director
2 operations
0
|
Machado Patrick | Director | 2 operations | – | 0 | – | 0 | – | Jun 1, 2026 | Jun 3, 2026 | |||||||||
|
Gover Justin D.
· Director
2 operations
0
|
Gover Justin D. | Director | 2 operations | – | 0 | – | 0 | – | Jun 1, 2026 | Jun 3, 2026 | |||||||||
|
Garofalo Elizabeth A.
· Director
2 operations
0
|
Garofalo Elizabeth A. | Director | 2 operations | – | 0 | – | 0 | – | Jun 1, 2026 | Jun 3, 2026 | |||||||||
|
Gannon Steven
· Director
2 operations
0
|
Gannon Steven | Director | 2 operations | – | 0 | – | 0 | – | Jun 1, 2026 | Jun 3, 2026 | |||||||||
|
Gannon Steven
· Director
Tax withholding or exercise payment (F)
-$76K
|
Gannon Steven | Director | Tax withholding or exercise payment (F) | $53.41 | -1K | -$76K | 12K | – | Jun 1, 2026 | Jun 3, 2026 | |||||||||
N
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287 reporting institutions disclosed XENE position changes in the Q1 2026 snapshot.
For each manager, WhoBought compares accepted consecutive 13F share counts. Share change is current shares minus prior shares. Estimated dollar change is that signed share change multiplied by the split-adjusted quarter-mean close. The activity table on this page uses Q1 2026.
An investor crossing 5% of a share class generally files Schedule 13D for activist intent or Schedule 13G for a passive position. The technical form names appear here rather than in the activity rows.
Ownership and institutional activity come from SEC Form 13F filings. Insider activity comes from SEC Form 4, and large-shareholder activity from SEC Schedules 13D and 13G. FMP supplies price data only. Company logos use the local verified Parqet cache with one shared fallback.
Form 13F is a quarterly disclosure and is normally filed after the quarter ends. Every ownership and activity value therefore names its represented period; it is not presented as a live position.
A muted dash marks a missing table value. It means the filing omitted the value, comparable data is unavailable, or no prior position exists for comparison.